Nano-sized particles already make bicycles and tennis rackets lighter and stronger, protect eyeglasses from scratches, and help direct chemotherapy drugs to cancer cells. But their usefulness depends on being able to precisely sculpt them into the right configurations—no easy task when they’re so tiny that thousands of them could fit into the thickness of a sheet of paper.
In a study published Dec. 3 in Nature Materials, University of Chicago scientists unveiled an innovative technique to push the boundaries of making such nanoparticles. They apply a coating which covers up parts of the nanoparticle, which allows them to coat new molecules on only the exposed surfaces—a bit like a stencil and a can of spray paint.
Nanoparticles are fascinating because they like to assemble themselves into shapes, so for a lot of applications, scientists can add the right ingredients and bake it at the right temperatures to get the shapes they want. But that only yields a certain range of possibilities.
“Most self-assembly is based on spheres, which don’t really have a difference in structure, but with most other shape it’s important to be able to get to specific areas,” said Yossi Weizmann, an assistant professor of chemistry and author on the paper. “You need deeper capabilities to more fully explore the possibilities of nanotechnology.”
The new method uses a coating of polymer spackled onto the nanoparticles in certain spots. Then you can add the next molecule, which can only attach to the nanoparticles where there is no polymer.
The resulting possibilities are only limited to a scientist’s imagination.
“The way we designed the building blocks lets you make a great number of permutations,” said graduate student Kyle Gibson, co-first author on the paper.
The nanoparticles are shaped by coating new molecules on certain parts of their surfaces. (Courtesy Chen & Gibson et al.)
They tested it and made a variety of shapes in nano-size—3-D cubes with only centers or edges and vertices exposed, 2-D prisms with free corners, and one-dimensional rods with only one side or one or both ends available.
The range of shapes allows scientists to experiment with properties, the scientists said, which could yield ideas for new electronics and sensing.
Other University of Chicago scientists on the study were Di Liu, PhD’16; graduate student Huw Rees; and postdoctoral fellows Gang Chen and Jung-Hoon Lee. Other co-authors came from Brookhaven National Laboratory and Columbia University.
Citation: “Regioselective surface encoding of nanoparticles for programmable self-assembly.” Chen & Gibson et al., Nature Materials, Dec. 3, 2018. Doi: 10.1038/s41563-018-0231-1
Funding: NSF, U.S. Department of Energy, University of Chicago, Martha Ann and Joseph A. Chenicek Graduate Research Fund, HHMI International Student Research Fellowship