Advancing understanding of artificial touch
In the first study, published in Nature Biomedical Engineering, Greenspon and his colleagues focused on ensuring that electrically evoked touch sensations are stable, accurately localized and strong enough to be useful for everyday tasks.
By delivering short pulses to individual electrodes in participants’ touch centers and having them report where and how strongly they felt each sensation, the researchers created detailed “maps” of brain areas that corresponded to specific parts of the hand. The testing revealed that when two closely spaced electrodes are stimulated together, participants feel a stronger, clearer touch, which can improve their ability to locate and gauge pressure on the correct part of the hand.
The researchers also conducted exhaustive tests to confirm that the same electrode consistently creates a sensation corresponding to a specific location.
“If I stimulate an electrode on day one and a participant feels it on their thumb, we can test that same electrode on day 100, day 1,000, even many years later, and they still feel it in roughly the same spot,” said Greenspon, who was the lead author on this paper.
From a practical standpoint, any clinical device would need to be stable enough for a patient to rely on it in everyday life. An electrode that continually shifts its “touch location” or produces inconsistent sensations would be frustrating and require frequent recalibration. By contrast, the long-term consistency this study revealed could allow prosthetic users to develop confidence in their motor control and sense of touch, much as they would in their natural limbs.
Adding feelings of movement and shapes
The complementary Science paper went a step further to make artificial touch even more immersive and intuitive. The project was led by first author Giacomo Valle, a former postdoctoral fellow at UChicago who is now continuing his bionics research at Chalmers University of Technology in Sweden.
“Two electrodes next to each other in the brain don’t create sensations that ‘tile’ the hand in neat little patches with one-to-one correspondence; instead, the sensory locations overlap,” explained Greenspon, who shared senior authorship of this paper with Bensmaia.
The researchers decided to test whether they could use this overlapping nature to create sensations that could let users feel the boundaries of an object or the motion of something sliding along their skin. After identifying pairs or clusters of electrodes whose “touch zones” overlapped, the scientists activated them in carefully orchestrated patterns to generate sensations that progressed across the sensory map.
Participants described feeling a gentle gliding touch passing smoothly over their fingers, despite the stimulus being delivered in small, discrete steps. The scientists attribute this result to the brain’s remarkable ability to stitch together sensory inputs and interpret them as coherent, moving experiences by “filling in” gaps in perception.
The approach of sequentially activating electrodes also significantly improved participants’ ability to distinguish complex tactile shapes and respond to changes in the objects they touched. They could sometimes identify letters of the alphabet electrically “traced” on their fingertips, and they could use a bionic arm to steady a steering wheel when it began to slip through the hand.
These advancements help move bionic feedback closer to the precise, complex, adaptive abilities of natural touch, paving the way for prosthetics that enable confident handling of everyday objects and responses to shifting stimuli.
The future of neuroprosthetics
The researchers hope that as electrode designs and surgical methods continue to improve, the coverage across the hand will become even finer, enabling more lifelike feedback.
“We hope to integrate the results of these two studies into our robotics systems, where we have already shown that even simple stimulation strategies can improve people’s abilities to control robotic arms with their brains,” said co-author Robert Gaunt, associate professor of physical medicine and rehabilitation and lead of the stimulation work at the University of Pittsburgh.
Greenspon emphasized that the motivation behind this work is to enhance independence and quality of life for people living with limb loss or paralysis.
“We all care about the people in our lives who get injured and lose the use of a limb — this research is for them,” he said. “This is how we restore touch to people. It’s the forefront of restorative neurotechnology, and we’re working to expand the approach to other regions of the brain.”
The approach also holds promise for people with other types of sensory loss. In fact, the group has also collaborated with surgeons and obstetricians at UChicago on the Bionic Breast Project, which aims to produce an implantable device that can restore the sense of touch after mastectomy.
Although many challenges remain, these latest studies offer evidence that the path to restoring touch is becoming clearer. With each new set of findings, researchers come closer to a future in which a prosthetic body part is not just a functional tool, but a way to experience the world.
Citations:
“Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.” Greenspon et al, Nature Biomedical Engineering, December 6, 2024. Funding: National Institutes of Health, Veterans Affairs.
“Tactile edges and motion via patterned microstimulation of the human somatosensory cortex.” Valle et al, Science, January 16, 2025. Funding: National Institutes of Health.
—Adapted from an article first published by UChicago Medicine.