Zoloth is a leader in the field of religious studies with a particular focus on bioethics and Jewish studies. Her scholarship includes the ethics of genetic engineering, stem cell research, and how science and medicine are taught. She is a founding board member of the Society for Scriptural Reasoning, and has been the president of the American Academy of Religion and the American Society for Bioethics and Humanities. Before joining UChicago, Zoloth served as a Charles McCormick Deering Professor of Teaching Excellence at Northwestern University, holding appointments in the Department of Religious Studies in the Weinberg College of Arts and Sciences and in the Feinberg School of Medicine.
Zoloth is the author of Health Care and the Ethics of Encounter: A Jewish Discussion of Social Justice and co-editor of five books, including Notes from a Narrow Ridge: Religion and Bioethics and Jews and Genes: The Genetic Future in Contemporary Jewish Thought.