Sarah Cobey, PhD, studies the ecology and evolution of pathogens, including how ecological and evolutionary processes can influence each other, and how pathogens compete in the complex environment of the host immune system. More recently, Asst. Prof. Cobey's focus has expanded to include the related dynamics of the host immune response. Investigating the evolution of antibody repertoires within hosts over time to identify the roles of infection history, chance, vaccination and other factors in generating the diversity of B cell responses.
In addition, she is the principal investigator at Cobey Lab, where research is tailored to study how the host adaptive immune response coevolves with pathogens, especially in ways relevant to vaccine design and pathogen diversity. The work is computational, and done in close collaboration with immunologists and epidemiologists.