Matthew Tirrell named founding director of Institute for Molecular Engineering

Matthew Tirrell, a pioneering researcher in the fields of biomolecular engineering and nanotechnology, has been appointed founding Pritzker Director of the University of Chicago’s new Institute for Molecular Engineering, effective July 1. The institute, created in partnership with Argonne National Laboratory, will explore innovative technologies that address fundamental societal problems through modern advances in nanoscale manipulation and the ability to design at a molecular scale.

Tirrell comes to UChicago from the University of California at Berkeley, where he has served since 2009 as the Arnold and Barbara Silverman Professor and chair of the Department of Bioengineering, as professor of materials science and engineering and chemical engineering, and as a faculty scientist at the Lawrence Berkeley National Laboratory. He has received many honors, including election to both the National Academy of Engineering and the American Academy of Arts and Sciences.

The appointment of Tirrell represents a critical step in the creation of the new Institute for Molecular Engineering, said University of Chicago President Robert J. Zimmer.

“Research in molecular engineering has the potential to yield extremely significant advances in both basic science and technology, as well as to create innovations in engineering education,” Zimmer said. “Matt Tirrell and the faculty of the new institute will benefit from its partnership with Argonne, opening the door to collaborations of profound impact.”

The creation of the institute brings a rare opportunity to help define a nascent field of study while drawing outstanding scientists from around the world, said University Provost Thomas F. Rosenbaum.

“Matt is the perfect leader for this new enterprise,” said Rosenbaum, who serves as the John T. Wilson Distinguished Service Professor in Physics. “He brings to the University and to Argonne deep appreciation for basic science, the sensibility of an accomplished engineer, and the vision to embrace fundamental problems of societal import.”

Prior to his appointment at Berkeley, Tirrell served for a decade as dean of engineering at UC Santa Barbara, where he helped build the program’s national prominence. He specializes in the manipulation and measurement of the surface properties of polymers, materials that consist of long, flexible, chain molecules. His work combines microscopic measurements of intermolecular forces with creation of new structures. His work has provided new insight into polymer properties, especially surface phenomena such as adhesion, friction, and biocompatibility, and new materials based on self-assembly of synthetic and bio-inspired materials.

Tirrell said he was excited by the prospect of forging a new kind of engineering program at UChicago, in partnership with Argonne researchers.

“This isn’t going to be directed narrowly toward one scientific discipline, but at creating an institute that attacks societal problems from a technological viewpoint,” he said. “Many important societal problems in energy or health care or the environment can be addressed by new molecular-level science. When you are trying to solve problems, you need people from different kinds of disciplines. That’s something the Institute for Molecular Engineering can create right from the beginning.”

Partnership with Argonne will be crucial

The institute’s partnership with Argonne, which will include a substantial presence at the lab, creates a powerful combination of research strengths crucial to the next generation of scientific discoveries, Tirrell said. Specifically, the institute will benefit from leading scientists and engineers and the world-class facilities at Argonne, including the Advanced Photon Source, the Argonne Leadership Computing Facility, and the Center for Nanoscale Materials.

"Given the energy, security, and environmental challenges our nation faces today, the institute comes at a critical time in our search to discover and deliver new solutions," said Argonne Director Eric D. Isaacs.

Molecular engineering is an emerging field that relies on new ways of fabricating and manipulating nanoscale structures to develop new technologies. The institute will have the potential to deliver fundamental advances in basic science, as well as findings that address pressing societal problems, ranging from energy supply and human health to clean water production and quantum computing.

 “We’re interested in the engineering of the future: how can you organize molecular systems to have a certain property or function,” said Steven Sibener, the Carl William Eisendrath Distinguished Service Professor in Chemistry, who headed two faculty committees that recommended forming the new institute and defined its ambitious horizons. “That’s a great opportunity that will require engineering disciplines.”

Erin Adams, an assistant professor in biochemistry & molecular biology who served on one of the faculty committees that recommended the institute, said that now is the perfect time for UChicago to pursue molecular engineering.

“The University doesn’t have a pre-existing engineering program, so the space is wide open for development, integrating new technologies, and also bringing together the research that we’re already doing on the biological and also the physical sciences level,” Adams said.

Institute researchers likely will pursue a variety of research that might include the development of smart materials or biologically inspired materials. A bridge built of smart materials might, for example, be able to signal when it has become dangerously stressed, or possibly even to repair itself. Biologically inspired materials, meanwhile, might consist of molecular components that could build muscle and tissue to heal severe injuries. Molecular engineers may also be able to devise faster computers that harness light rather than electrons to perform their operations. Researchers foresee applications of molecular engineering in clinical medicine, such as in bioengineered structures or the study of complex systems of cell signaling.

“This is a singular moment in history when our ability to create and control materials at the molecular scale promises to transform the way we engineer solutions to the key scientific and technological challenges of our time,” said Amanda Petford-Long, Director of the Center for Nanoscale Materials at Argonne.

Another benefit of the partnership with Argonne is the lab’s experience in shepherding projects with the potential for industrial and commercial applications, such as Argonne’s licensing of innovative battery technology for use in hybrid automobiles. The new institute has the potential to create new findings with commercial uses. University and laboratory leaders believe that intellectual property from the institute will help strengthen the Chicago-area economy, and lead to even more robust regional activity for cutting-edge engineering and biotechnology companies.

Internal, external committees recommended new Institute

The institute is the largest new academic program that the University has started since the founding of the University of Chicago Harris School of Public Policy Studies in 1988. Molecular Engineering will have a target size of 24 faculty members, many of them with joint appointments at Argonne, who will be recruited over the next decade to work in four to six thematic areas to be determined by the director and other faculty.

The faculty of the institute will develop introductory and specialized courses, and later will propose a curriculum in molecular engineering to support an undergraduate major as well as graduate degrees, which will require separate faculty approval.

The establishment of the new institute followed three years of discussion and review. Sibener headed two ad hoc committees, one in 2007 and one in 2009, which President Zimmer and Provost Rosenbaum charged with assessing the possibility of establishing a formal molecular engineering program at the University. The work of the committees flowed from molecular research developments in recent years as basic sciences, including physics, chemistry, and biology, began new collaborations with once-distinct engineering disciplines.

Sibener’s committees, including faculty members from the University’s Physical and Biological Sciences divisions, enthusiastically endorsed the creation of a molecular engineering program, as did an external committee chaired by Robert Langer of the Massachusetts Institute of Technology. The faculty Council of the Senate’s vote to create the institute was followed by endorsement of the University’s Board of Trustees in March 2010.

Construction will begin in September 2011 on the William Eckhardt Research Center, which will house the new institute as well as several programs of the Physical Sciences Division.

The WERC is named for Chicago futures trader and alumnus William Eckhardt, S.M.’70, in recognition of a generous gift he made in support of scientific research at the University. The Pritzker Directorship is named in honor of the Pritzker Foundation, which has made a generous gift in support of the Institute for Molecular Engineering. This major gift of the Pritzker family adds to the family’s long history of support of the University of Chicago. Thomas J. Pritzker is a Trustee of the University.

Tirrell began his academic career in 1977 at the University of Minnesota, where he served as Shell Distinguished Chair in Chemical Engineering, Earl E. Bakken Professor of Biomedical Engineering, director of the Biomedical Engineering Institute, and head of Chemical Engineering and Materials Science.

Tirrell moved to the University of California, Santa Barbara, in 1999, where for a decade he was Professor of Chemical Engineering, Materials, Biomolecular Science and Engineering, and Richard A. Auhll Professor and Dean of the College of Engineering.

He received his bachelor’s degree in chemical engineering from Northwestern University in 1973 and his doctoral degree in polymer science and engineering from the University of Massachusetts in 1977.



Matthew Tirrell, the founding Pritzker Director of the Institute for Molecular Engineering, discusses his vision for IME (2011)

Steven Sibener: Establishing the Institute for Molecular Engineering

Erin Adams and Thomas Rosenbaum: 'Defining a New Type of Engineering'

University partnership in Molecular Engineering with Argonne National Laboratory


Matthew Tirrell
Steven Sibener
Rough Waters
Erin Adams with student
Cellular proteins
Luping Yu
Eckhardt Center

This artistic rendering depicts some of the circulating nanoparticles studied by Matthew Tirrell’s research group at the University of California at Berkeley. The goal is to engineer such nanoparticles for diagnostic or therapeutic purposes.

Courtesy of Matthew Tirrell

Matthew Tirrell will become the founding Pritzker Director of UChicago’s Institute for Molecular Engineering on July 1. He is currently a faculty member at UC Berkeley and a faculty scientist at the Lawrence Berkeley National Laboratory.

Photo by Lloyd DeGrane

Steven Sibener, the Carl William Eisendrath Distinguished Service Professor in Chemistry and the James Franck Institute, chaired faculty committees in 2006-2007 and again in 2009 that recommended the establishment of a molecular engineering program at the University of Chicago. “In any field of research, there’s a critical moment when revolutionary change can occur,” Sibener said. “That moment is upon us for molecular engineering.”

Photo by Dan Dry

The product of research collaboration between scientists at Argonne National Laboratory and the University of Chicago, this stylized image is a snapshot of how molecules organize themselves in films.

Courtesy of Seth Darling, Steven Sibener

Erin Adams (left), Assistant Professor in Biochemistry & Molecular Biology, is exploring the structure of immune system proteins to understand how they effectively ward off a variety of diseases and disorders, including cancer, pathogenic viruses and bacteria. Adams’ research group includes Adrienne Luoma, Committee on Immunology graduate student (right). Adams was part of a University faculty committee on Molecular Engineering.

Photo by Dan Dry

Protein crystals and X-ray beams allow researchers in Erin Adams’ research group in Biochemistry & Molecular Biology to determine the three-dimensional structures of the many cellular proteins they have under investigation in her laboratory. All of her projects have a structure-determination component to them, and most of them are related to the immune system.

Photo by Dan Dry

Institute for Molecular Engineering faculty will explore innovative technologies through nanoscale manipulation and the ability to design at a molecular scale. Here UChicago chemists Luping Yu (right) and Yongye Liang display a new material they synthesized called PTB1. The University has licensed the material to Solarmer Energy Inc., which is developing plastic solar cells for portable electronic devices.

Photo by Lloyd DeGrane

Construction will begin in September 2011 on the new William Eckhardt Research Center, which will house the Institute for Molecular Engineering as well as numerous programs and departments in the Physical Sciences Division. The institute is the largest new department launched at UChicago since the University of Chicago Harris School of Public Policy in 1988.

Illustration by AJSNY, HOK, James Carpenter Design Associates Inc. (JCDA)

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